Delim Cosmetics & Pharma, a Contract Research Organization (CRO) based in Milan, Italy, has advanced its pharmaceutical R&D capabilities by employing cutting-edge solid-state transformation techniques like spray drying amorphization and solvent wetting granulation. These methods allow the conversion of crystalline drugs into their amorphous states, which significantly improves bioavailability, solubility, and absorption of Active Pharmaceutical Ingredients (APIs).
- Spray drying amorphization: Delim uses this scalable technique to rapidly dry API solutions into amorphous fine powders. The rapid drying process prevents crystallization, resulting in increased solubility and dissolution rates.
- Solvent wetting granulation: This method involves dissolving poorly water-soluble drugs in a solvent, dispersing them onto a solid polymeric carrier, ensuring uniform granulation, and avoiding recrystallization.
While amorphization enhances bioavailability, Delim tackles the inherent instability of amorphous forms with stabilizing agents like polymers to ensure long-term efficacy. These innovations position Delim as a leader in developing both novel and generic pharmaceutical formulations, spanning therapeutic areas like dermatology, gynecology, oncology, and more.
For further details, visit Delim Cosmetics & Pharma.
